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Search Results for " il 9 "

Targets Recommended: IL Receptor

10

抑制剂 & 化合物

4

天然产物

1

化合物库

24

重组蛋白

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Cat. No.	Product Name
L7600	趋化因子抑制剂库		59 compounds
	59 种趋化因子或其受体抑制剂的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

趋化因子抑制剂库

Cat.No: L7600

Compounds: 59

Cat. No.	Product Name	Target	Signaling Pathways
T76744	Enokizumab MEDI-528	IL Receptor	Immunology/Inflammation
	Enokizumab (MEDI-528) 是一种针对白介素 IL-9 的单克隆抗体。Enokizumab 可用于研究哮喘疾病。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
T27967	M199
	M199, a novel inhibitor of TLR3/9 activation, induces secretion of IL-6, IL-8 and TNFalpha in human PBMCs.
T72102	Glucocorticoid receptor modulator 1
	Glucocorticoid receptor modulator1 是一种高效且具有口服活性的 NF-κB 和 AP-1抑制剂，IC50分别为 9 nM 和 130 nM。Glucocorticoid receptor modulator1 可有效降低炎症因子 IL-6、IL-1β、TNF-α 的表达，可缓解小鼠皮炎。
T71839	ATV399
	ATV399 is an inhibitor of iNOS dimerization which protects against Cytokine-Induced rat β-cell dysfunction, thereby inhibiting cleaved caspase-9 activation and subsequent β-cell apoptosis induced by a combination of IL-1β, IFN-γ, and high glucose.
T37313	ITH15004
	ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 μM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor when used at a concentration of 100 μM. ITH15004 (1 μM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA). 1.Calzaferri, F., Narros-Fernández, P., de Pa...
T64280	ODN 2216
	ODN 2216 是一种 TLR9 (toll-like receptor 9) 配体或激动剂，能够诱导产生大量的 IFN-α 和 IFN-β。ODN 2216 可以利用 pDC (浆细胞样 DC) 诱导 IFN-α，以及利用 DC (树突状细胞) 产生IL-12 (p40)。ODN 2216 能够间接的、在 IFN-α/β 介导下刺激外周血单核细胞 (PBMC) 产生 IFN-γ。ODN 2216 可以激活 NK 细胞，诱导 IFN-γ 产生 TCR 触发的 CD4+T 细胞。
T71212	Lornoxicam-d4
	Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes whe...
T36648	Tucatinib hemiethanolate
	Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-fold selective for HER2 versus EGFR in cell-based assays. Tucatinib selectively inhibits the receptor tyrosine kinase HER2 relative to EGFR[1].Tucatinib blocks proliferation and the phosphorylation of HER2 and its downstream effector, Akt in HER2 overexpressing cell lines. In the ...

化合物

Cat.No: T76744

Synonym: MEDI-528

Target: IL Receptor

Cat.No: T15017

Target: TLR

Cat.No: T27967

Glucocorticoid receptor modulator 1

Cat.No: T72102

Cat.No: T71839

Cat.No: T37313

Cat.No: T64280

Cat.No: T71212

β-Defensin-2 (human) (trifluoroacetate salt)

Cat.No: T35451

Tucatinib hemiethanolate

Cat.No: T36648

Cat. No.	Product Name	Target	Signaling Pathways
T4S0795	Berberrubine chloride 9-Berberoline Chloride,Beroline,Beroline Chloride,小檗红碱,Berberrubine,9-Berberoline	IL Receptor	Immunology/Inflammation
	Berberrubine chloride (9-Berberoline Chloride) 是一种黄连素的有效代谢物，能够改善动物模型中溃疡性结肠炎的症状。
TN1056	Mogroside IIe	IL Receptor	Immunology/Inflammation
	Mogroside IIe 是一种天然来源的三萜糖苷，作为非糖类甜味剂，Mogroside 比蔗糖更甜。Mogroside 具有抗氧化，抗糖尿病和抗癌活性。
T5S2059	Glaucine	Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Glaucine 是从海罂粟中分离的一种生物碱，具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂，具有抗氧化和抗病毒活性。
TN5033	Skullcapflavone I	IL Receptor; Caspase; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se

天然产物

Berberrubine chloride

Cat.No: T4S0795

Synonym: 9-Berberoline Chloride,Beroline,Beroline Chloride,小檗红碱,Berberrubine,9-Berberoline

Target: IL Receptor

Cat.No: TN1056

Target: IL Receptor

Cat.No: T5S2059

Target: Calcium Channel, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, PDE

Skullcapflavone I

Cat.No: TN5033

Target: IL Receptor, Caspase, Prostaglandin Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01870	IL-9 Protein, Human, Recombinant (His) P40,interleukin 9,HP40,白细胞介素,IL-9...	Human	Baculovirus Insect Cells
	IL-9 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 15.5 kDa and the accession number is P15248.
TMPK-00474	IL-22RA1 Protein, Cynomolgus, Recombinant (His) CRF2-9,IL22R1,IL-22R-α-1,IL	Cynomolgus	HEK293 Cells
	IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activatio...
TMPY-05221	IL-9 Protein, Mouse, Recombinant (His) Il-9,白细胞介素,interleukin 9,白介素,P40	Mouse	Baculovirus Insect Cells
	IL-9 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 15.6 kDa and the accession number is P15247.
TMPK-00568	IL-9 Protein, Cynomolgus, Recombinant (His) P40,HP40,IL-9,T-cell growth factor P40,Int...	Cynomolgus	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Cynomolgu...
TMPK-00026	IL-9 Protein, Mouse, Recombinant (hFc) P40,IL-9,Interleukin-9,Cytokine P...	Mouse	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Mouse, Re...
TMPK-00025	IL-9 Protein, Human, Recombinant (hFc) HP40,Cytokine P40,白细胞介素,Interleukin-9,白介素,P40,T-cel...	Human	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Human, Re...
TMPK-01071	IL-22RA1 Protein, Mouse, Recombinant (hFc) IL-22R α1,IL22R,zcytoR11,IL-TIF-R...	Mouse	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. IL-22RA1 Pr...
TMPK-01105	IL-22RA1 Protein, Human, Recombinant (hFc) IL-22R-alpha-1,CRF2-9,IL-TIF-R1,<...	Human	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. IL-22RA1 Pr...
TMPY-00459	IL-9 Protein, Rat, Recombinant (His) 白介素,白细胞介素,interleukin 9	Rat	Baculovirus Insect Cells
	IL-9 Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 15.6 kDa and the accession number is A6KAN0.
TMPY-02624	IL-9R Protein, Rat, Recombinant (His) interleukin 9 receptor	Rat	HEK293 Cells
	IL9R (Interleukin 9 Receptor) is a Protein Coding gene. The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). IL9 is involved in mast cell maturation and the enhancement of IgE production by B cells. Furthermore, linkage data in the human and mice have suggested that IL9 may contribute to asthma. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to differe...
TMPY-00851	IL-1 R9 Protein, Human, Recombinant (hFc) IL-1R9,interleukin 1 receptor accessory pr...	Human	HEK293 Cells
	IL-1 R9 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66 kDa and the accession number is Q9NP60.
TMPY-01740	IL-1 R9 Protein, Human, Recombinant (His) IL-1R9,IL1RAPL-2,IL1R	Human	HEK293 Cells
	IL-1 R9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.7 kDa and the accession number is Q9NP60.
TMPJ-00865	VEGF121 Protein, Human, Recombinant (His) VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生...	Human	HEK293 Cells
	Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPY-03698	VEGF121b Protein, Human, Recombinant MVCD1,VEGF,VPF,vascular endothelial growth factor A	Human	HEK293 Cells
	VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9.
TMPH-00005	YAP1 Protein, Human, Recombinant (Isoform 9, His) YAP1-2delta	Human	P. pastoris (Yeast)
	YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9.
TMPJ-00239	IL-2RG Protein, Mouse, Recombinant (aa 25-263, hFc) Il2rg,Interleukin 2 receptor, gamma chain, isoform ...	Mouse	HEK293 Cells
	The Interleukin-2 receptor gamma chain (IL-2 Rγ, CD132) of the high affinity functional mouse IL-2 receptor complex is a member the hematopoietin receptor family. It is expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. Common IL2 receptor-γ Chain is required for IL-2 receptor signaling. Besides IL-2, the Common IL2 receptor-γ chain has been shown to be a component of the functional receptor complexes for IL-4, IL-7, IL-9 and IL-15....
TMPY-04817	Syntenin Protein, Human, Recombinant (His) MDA-9,SYCL,TACIP18,syndecan binding protein (synten...	Human	E. coli
	Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. IL-6 promotes glioma cell proliferation and invasion by inducing SDCBP expression, which is mediated by JAK2/STAT3 signaling. SDCBP might be an important marker for identifying Triple negative breast cancer (TNBC) cases that are suitable for dasatinib therapy.
TMPJ-01283	UGRP1 Protein, Human, Recombinant Uteroglobin-Related Protein 1,Secretoglobin Family ...	Human	E. coli
	Uteroglobin-Related Protein 1 (UGRP1) belongs to the secretoglobin family which has been suggested to play a role in lung inflammation and allergic diseases. UGRP1 is a 17 kDa secreted homodimeric protein that shows amino acid sequence similarity with uteroglobin. UGRP1 is expressed predominantly in the lung and low levels of expression are detected in the thyroid. Expression of UGRP1 in lung epithelial cells is enhanced by IL-10 and decreased through the activities of IL-9 and IL-5. UGRP1 inter...
TMPJ-01060	CXCL6 Protein, Human, Recombinant (His) SCYB6,Chemokine Alpha 3,CKA-3,GCP2,GCP-2,C-X-C Motif Chemoki...	Human	HEK293 Cells
	Chemokine (C-X-C-Motif) Ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family. It is a potent neutrophil chemotactic and activating factor and it exhibits extensive similarity to other CXC chemokines such as IL-8 and ENA-78. CXCL6 can promote the release of MMP-9 from granulocytes indicating its potential role as an inflammatory mediator. It functionally uses both of the IL-8/CXCL8 receptors to chemoattract neutrophils but that is structurally most related to epithelial cell...
TMPJ-00145	4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc) Tumor necrosis factor receptor superfamily member <...	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells...
TMPJ-01187	Siglec-E Protein, Mouse, Recombinant (hFc) SiglecE,Siglec-E	Mouse	HEK293 Cells
	Siglecs are sialic acid specific I‑type lectins that are characterized by an extracellular domain (ECD) with an N‑terminal Ig‑like V‑set domain followed by varying numbers of Ig‑like C2‑set domains. Mouse Siglec‑E, also known as Myeloid Inhibitory Siglec (MIS), is an 80 ‑ 85 kDa member of the CD33‑related subfamily of Siglecs. Rodent and primate Siglec gene families have significantly diverged, and Siglec‑9 is the most likely human ortholog of mouse Siglec‑E. Siglec‑E is expressed as a heavily N...
TMPK-00825	VEGF121 Protein, Human, Recombinant (His & Avi) VPF,VEGF,VEGFA,VEGFMGC70609,血管内皮生长因子,MGC70609	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPK-00826	VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,VEGFA,VPF,MV...	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPY-05268	Neurofascin Protein, Human, Recombinant (hFc), Biotinylated NRCAML,neurofascin,NF	Human	HEK293 Cells
	Neurofascin Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-9.

重组蛋白

IL-9 Protein, Human, Recombinant (His)

Cat.No: TMPY-01870

Species: Human

Expression System: Baculovirus Insect Cells

IL-22RA1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00474

Species: Cynomolgus

Expression System: HEK293 Cells

IL-9 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05221

Species: Mouse

Expression System: Baculovirus Insect Cells

IL-9 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00568

Species: Cynomolgus

Expression System: HEK293 Cells

IL-9 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00026

Species: Mouse

Expression System: HEK293 Cells

IL-9 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00025

Species: Human

Expression System: HEK293 Cells

IL-22RA1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01071

Species: Mouse

Expression System: HEK293 Cells

IL-22RA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01105

Species: Human

Expression System: HEK293 Cells

IL-9 Protein, Rat, Recombinant (His)

Cat.No: TMPY-00459

Species: Rat

Expression System: Baculovirus Insect Cells

IL-9R Protein, Rat, Recombinant (His)

Cat.No: TMPY-02624

Species: Rat

Expression System: HEK293 Cells

IL-1 R9 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00851

Species: Human

Expression System: HEK293 Cells

IL-1 R9 Protein, Human, Recombinant (His)

Cat.No: TMPY-01740

Species: Human

Expression System: HEK293 Cells

VEGF121 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00865

Species: Human

Expression System: HEK293 Cells

VEGF121b Protein, Human, Recombinant

Cat.No: TMPY-03698

Species: Human

Expression System: HEK293 Cells

YAP1 Protein, Human, Recombinant (Isoform 9, His)

Cat.No: TMPH-00005

Species: Human

Expression System: P. pastoris (Yeast)

IL-2RG Protein, Mouse, Recombinant (aa 25-263, hFc)

Cat.No: TMPJ-00239

Species: Mouse

Expression System: HEK293 Cells

Syntenin Protein, Human, Recombinant (His)

Cat.No: TMPY-04817

Species: Human

Expression System: E. coli

UGRP1 Protein, Human, Recombinant

Cat.No: TMPJ-01283

Species: Human

Expression System: E. coli

CXCL6 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01060

Species: Human

Expression System: HEK293 Cells

4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00145

Species: Mouse

Expression System: HEK293 Cells

Siglec-E Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01187

Species: Mouse

Expression System: HEK293 Cells

VEGF121 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00825

Species: Human

Expression System: HEK293 Cells

VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00826

Species: Human

Expression System: HEK293 Cells

Neurofascin Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05268

Species: Human

Expression System: HEK293 Cells

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